Sermorelin (5mg)
Sermorelin is a GHRH (Growth Hormone Releasing Hormone) analog that stimulates the pituitary gland's natural production of growth hormone. Reconstitute with 2mL of bacteriostatic water for a concentration of 2.5mg/mL (250mcg per 10 units).
Reviewed by the AllPeptides.eu Editorial Team·Last reviewed: 2026-06-16
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
⚠️ For informational/educational purposes only. Not medical advice. We do not sell any products. Self-treatment carries serious risks — consult a healthcare professional. Disclaimer
Research monograph
See the full Sermorelin encyclopedia page with mechanism, evidence tier, related variants and research context.
How It Works
Sermorelin binds to GHRH receptors in the pituitary gland, triggering the pulsatile release of growth hormone. This increases IGF-1 levels, improving tissue regeneration, fat metabolism, and protein synthesis.
Quick Start
- Typical dose: 200–300mcg subcutaneously, before bedtime
- Frequency: Daily or 5 days/week
- Storage: 2–8°C after reconstitution, use within 28 days
Dosing Table — Sermorelin 5mg
Route: Subcutaneous injection | Frequency: Daily, before bedtime
| Week | Dose | Units (per injection) |
|---|---|---|
| 1–2 | 200mcg | 8 Units (0.08 mL) |
| 3–4 | 250mcg | 10 Units (0.10 mL) |
| 5+ | 300mcg | 12 Units (0.12 mL) |
Studies report administration before bedtime on an empty stomach for optimal pulsatile GH release. Avoid food 2 hours prior.
Related compounds
Reconstitution Steps
- Clean the vial and bacteriostatic water stoppers with an alcohol wipe.
- Draw 2mL of bacteriostatic water into a syringe.
- Inject slowly against the side of the vial — do not shake.
- Gently swirl until fully dissolved.
- Store in the refrigerator (2–8°C). Use within 28 days.
Protocol Overview
- Sermorelin mimics the action of natural GHRH, stimulating the pituitary gland to secrete growth hormone.
- It preserves the natural feedback mechanism, minimizing the risk of excessive GH.
- Results appear gradually over 3–6 months of use.
Dosing Protocol
- Start with 200mcg/day and gradually increase to 300mcg.
- Administer before bedtime on an empty stomach.
- Cycle: 3–6 months on, 1 month off.
- Can be combined with Ipamorelin or GHRP-2 for synergistic action.
- Break between cycles: After the cycle (3–6 months), a washout period of 4–8 weeks is recommended. The break prevents tolerance to the GHRH receptor and allows for evaluation of results.
Washout & Cycle Restart
When can I restart?
After the cycle (3–6 months), a washout period of 4–8 weeks is recommended. The break prevents tolerance to the GHRH receptor and allows for evaluation of results.
Minimum wait period: 4 weeks
Storage Instructions
- Lyophilized powder: room temperature or refrigerator.
- Reconstituted solution: 2–8°C, use within 28 days.
- Do not freeze after reconstitution.
Important Notes
- Avoid food rich in fats or carbohydrates 2 hours before administration.
- Sleep quality typically improves within 1–2 weeks.
- Consult a physician before use, especially if you have a history of neoplasia.
Potential Benefits & Side Effects
Potential Benefits:
- Increased natural production of growth hormone
- Improved sleep quality
- Enhanced muscle growth and recovery
- Reduced body fat
- Improved skin elasticity
Potential Side Effects:
- Irritation at the injection site
- Transient headache
- Flushing
- Rarely: dizziness or nausea
⚠️ Serious Warnings & Long-Term Risks
The following warnings are based on published literature, FDA labels, and post-marketing surveillance. They do not constitute medical advice. Consult a healthcare professional.
Theoretical risk (IGF-1 elevation)
As a GHRH analogue, increases GH/IGF-1. Same theoretical concern as exogenous GH, but to a lesser degree due to physiological regulation.
📄 FDA Label — Geref® (withdrawn)References
- Sermorelin: GHRH Analog — Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clin Interv Aging. 2006;1(4):307-308.
View Source - Growth Hormone Secretagogues — Sigalos JT, Pastuszak AW. The Safety and Efficacy of Growth Hormone Secretagogues. Sex Med Rev. 2018;6(1):45-53.
View Source
Recommended Supplements
L-Arginine + L-Ornithine
ZMA (Zinc + Magnesium + B6)
External Sources & Regulatory Status
Regulatory Approvals
Geref® · GH deficiency (children) (1997)
FDA approved (withdrawn 2008)
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
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