Semax (5mg)
Semax is a synthetic peptide derivative of ACTH(4-10) with neuroprotective and nootropic properties. Reconstitute with 2mL of bacteriostatic water for a concentration of 2.5mg/mL (250mcg per 10 units).
Reviewed by the AllPeptides.eu Editorial Team·Last reviewed: 2026-06-16
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
⚠️ For informational/educational purposes only. Not medical advice. We do not sell any products. Self-treatment carries serious risks — consult a healthcare professional. Disclaimer
Research monograph
See the full Semax encyclopedia page with mechanism, evidence tier, related variants and research context.
How It Works
Semax works by increasing BDNF, modulating dopamine/serotonin, improving cerebral circulation, and providing neuroprotection against oxidative stress.
Quick Start
- Typical dose: 200–600mcg intranasally or subcutaneously
- Frequency: 1–2x/day
- Storage: 2–8°C after reconstitution
Dosing Table — Semax 5mg
Route: Intranasal or subcutaneous | Frequency: 1–2x daily
| Week | Dose | Units (per injection) |
|---|---|---|
| 1–2 | 100–200mcg | 4–8 Units (0.04–0.08 mL) |
| 3–4 | 200–400mcg | 8–16 Units (0.08–0.16 mL) |
| 5+ | 400–600mcg | 16–24 Units (0.16–0.24 mL) |
Studies report administration in the morning/midday. Onset of action is within 15–30 minutes intranasally. Cycle for 2–4 weeks.
Related compounds
Reconstitution Steps
- Clean the vial stoppers with an alcohol wipe.
- Draw up 2mL of bacteriostatic water.
- Slowly inject down the side of the vial.
- Gently swirl until fully dissolved.
- Store in the refrigerator (2–8°C).
Protocol Overview
- Semax is a synthetic analog of ACTH(4-10) with a modified C-terminus.
- It was developed in Russia and is used clinically as a nootropic.
- It significantly increases BDNF and improves cognitive function.
Dosing Protocol
- Start with 100–200mcg, 1x/day.
- Increase to 400–600mcg, 1–2x/day.
- Cycle: 2–4 weeks on, 1–2 weeks off.
- Combines excellently with Selank for anxiolytic/nootropic effects.
- Break between cycles: After a cycle (2–4 weeks), a break of 2–4 weeks is recommended. Semax does not cause dependency, but the break helps prevent tolerance to its effects.
Washout & Cycle Restart
When can I restart?
After a cycle (2–4 weeks), a break of 2–4 weeks is recommended. Semax does not cause dependency, but the break helps prevent tolerance to its effects.
Minimum wait period: 2 weeks
Storage Instructions
- Reconstituted: 2–8°C, use within 30 days.
- Powder: -20°C or 2–8°C.
Important Notes
- Intranasal administration is the most common and effective.
- Significantly increases BDNF levels.
- Does not cause dependence or tolerance.
Potential Benefits & Side Effects
Potential Benefits:
- Improved memory and learning
- Enhanced concentration and focus
- Neuroprotection (BDNF increase)
- Anxiolytic effect without sedation
- Improved cerebral circulation
Potential Side Effects:
- Mild headache (rare)
- Nasal dryness (intranasal)
- Rarely: insomnia if taken late
⚠️ Serious Warnings & Long-Term Risks
The following warnings are based on published literature, FDA labels, and post-marketing surveillance. They do not constitute medical advice. Consult a healthcare professional.
Neurotrophic action — uncertain long-term effects
Semax increases BDNF, NGF, and modifies dopaminergic/serotonergic signaling. Long-term use may theoretically alter neuroplasticity. No studies >6 months in humans.
📄 Neurosci Lett 2006References
- Semax Neuroprotection — Levitskaya NG, et al. Neuroprotective effects of Semax in conditions of MPTP-induced neurodegeneration. Neurosci Behav Physiol. 2004;34(4):399-405.
View Source - Semax & Neurotrophin Gene Activation — Dmitrieva VG, et al. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. Cell Mol Neurobiol. 2010;30(1):71-79.
View Source
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External Sources & Regulatory Status
Regulatory Approvals
Stroke / Cognitive enhancement (2001)
Approved in Russia (2001)
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
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