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Semax (Nasal Spray)
Semax (ACTH 4-10 analogue) is a regulatory neuropeptide approved in Russia for cognitive enhancement and neuroprotection in the form of a nasal spray.
Reviewed by the AllPeptides.eu Editorial Team·Last reviewed: 2026-06-16
Mechanism of Action
Semax acts as a neurotrophic agent, with research data suggesting it enhances BDNF (Brain-Derived Neurotrophic Factor). Studies — primarily Russian — report improvements in memory, attention, and neuroprotection. Nasal administration is being studied as a potential route of access to the CNS.
Overview
- Administered intranasally — no injection required
- Research data primarily from Russian clinical studies
- Dosages range from 200–600 mcg/day in clinical studies
- Self-preparation of nasal spray is not recommended
Intranasal Delivery — Research Data
- Semax has been studied extensively in its nasal form, primarily in Russia, for neuroprotective applications.
- Approved drug in Russia in the form of a nasal spray (0.1% and 1%).
- Bioavailability via the nasal route is considered satisfactory based on clinical data, although the exact absorption mechanisms remain under investigation.
Stronger intranasal relevance
Clinical studies or approved formulations exist for intranasal delivery.
Dosing Table — Semax Nasal Spray
| Period | Dose | Notes |
|---|---|---|
| Typical Dose | 200–600 mcg/day | 2–6 sprays (depends on concentration) |
Doses are based on published clinical data. Self-administration instructions are not provided.
Formulation Notes
No self-preparation instructions provided
- Commercial formulations in Russia are available as ready-to-use nasal solutions — no user reconstitution is required.
- Self-preparation of nasal spray from powder is not recommended due to risks of sterility and dosing accuracy.
Storage After Opening
- Store in a refrigerator (2–8°C) after opening.
- Use within 10–14 days of first opening (depending on the manufacturer).
- Avoid exposure to direct sunlight.
Dosing Protocol
- Clinical doses: 200–600 mcg daily, divided into 2–3 applications.
- Cycles of 10–14 days in clinical studies.
- The exact dosage depends on the formulation's concentration.
Storage Instructions
- Refrigerator (2–8°C) before and after opening.
- Store away from light and heat.
- After first opening, use within 10–14 days.
Important Notes
- Semax is not approved by the FDA or EMA.
- Research data comes primarily from Russian studies — there are no large-scale Western clinical trials.
- Self-preparation instructions for the nasal spray are not provided.
- Consult a healthcare professional before use.
Benefits & Side Effects
Potential Benefits
- Enhancement of cognitive function (memory, attention)
- Neuroprotective properties (research data)
- Research data suggest an anxiolytic effect with a low sedative profile
- Rapid absorption via the nasal route
Potential Side Effects
- Mild nasal irritation
- Rare: headache, dizziness
- Long-term safety not fully documented in Western studies
References
Intranasal Peptide Delivery: Complete Guide
Bioavailability, absorption factors, comparison with injectables, and limitations of nasal delivery.
Research Limitations
The data on this page is strictly educational. No self-preparation or self-administration instructions are provided.
External Sources & Regulatory Status
Regulatory Approvals
Stroke / Cognitive enhancement (2001)
Approved in Russia (2001)
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
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