Pentosan Polysulfate (PPS) (250mg)
Pentosan Polysulfate (PPS / Elmiron®) is a semisynthetic heparinoid with chondroprotective properties. It is supplied as a ready-to-use injectable solution or per os capsules.
Reviewed by the AllPeptides.eu Editorial Team·Last reviewed: 2026-06-16
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
⚠️ For informational/educational purposes only. Not medical advice. We do not sell any products. Self-treatment carries serious risks — consult a healthcare professional. Disclaimer
How It Works
PPS inhibits metalloproteinases (MMPs), protects cartilage proteoglycans, reduces inflammation via NF-κB, and enhances hyaluronic acid synthesis.
Quick Start
- Typical Dose: 2–3mg/kg subcutaneously or 100mg per os
- Frequency: 1–2x/week (injection) or 3x/day (per os)
- Storage: Room temperature
Dosing Table — PPS 250mg
Route: Subcutaneous / Intramuscular / Per os | Frequency: 1–2x weekly (injection)
| Week | Dose | Units (per injection) |
|---|---|---|
| 1–4 | 2mg/kg | 1.6 Units (0.02 mL) |
| 5–8 | 3mg/kg | 2.4 Units (0.02 mL) |
| Elmiron® | 100mg | 80 Units (0.80 mL) |
Injection cycle: 4–6 weeks. Per os (Elmiron®): 3–6 months for interstitial cystitis.
Related compounds
Reconstitution Steps
- PPS is typically supplied as a ready-to-use injectable solution.
- Clean the rubber stopper with an alcohol wipe.
- Draw the desired dose.
- Administer subcutaneously or intramuscularly.
Protocol Overview
- PPS is a semisynthetic heparinoid derived from beechwood bark.
- Chondroprotective, anti-inflammatory, and antithrombotic effects.
- Elmiron® is approved for interstitial cystitis (IC/BPS).
Dosing Protocol
- Injection: 2–3mg/kg, 1x/week for 4–6 weeks.
- Per os: 100mg 3x/day (Elmiron® dose).
- For OA: 4–6 week cycles, 2x/year.
- Results: 2–4 weeks (injection), 3–6 months (per os).
- Break between cycles: After an injection cycle (4–6 weeks), a washout period of 2–3 months is recommended before repeating. Typically 2 cycles/year.
Washout & Cycle Restart
When can I restart?
After an injection cycle (4–6 weeks), a washout period of 2–3 months is recommended before repeating. Typically 2 cycles/year.
Minimum wait period: 8 weeks
Storage Instructions
- Room temperature (15–25°C).
- Protect from light.
Important Notes
- May increase bleeding time.
- Avoid concurrent use of anticoagulants.
- Long-term per os use: rare retinal maculopathy.
Potential Benefits & Side Effects
Potential Benefits:
- Chondroprotection and regeneration
- Anti-inflammatory action in joints
- Improved mobility
- Thrombolytic properties
- Bladder protection (IC)
Potential Side Effects:
- Increased bleeding time
- Mild gastrointestinal effects (per os)
- Rare: maculopathy (long-term per os use)
- Bruising at the injection site
⚠️ Serious Warnings & Long-Term Risks
The following warnings are based on published literature, FDA labels, and post-marketing surveillance. They do not constitute medical advice. Consult a healthcare professional.
Retinopathy (Maculopathy)
Chronic use of pentosan polysulfate (>3 years) is associated with irreversible retinal damage (pigmentary maculopathy). FDA added a warning in 2020.
📄 Ophthalmology 2018; FDA Safety Communication 2020References
- PPS Osteoarthritis — Ghosh P, et al. The effects of pentosan polysulfate on cartilage proteoglycans. Semin Arthritis Rheum. 1999;28(4):211-267.
View Source - Elmiron IC/BPS — Nickel JC, et al. Randomized, double-blind, dose-ranging study of pentosan polysulfate sodium for interstitial cystitis. Urology. 2005;65(4):654-658.
View Source
Recommended Supplements
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Collagen Peptides
External Sources & Regulatory Status
Regulatory Approvals
Elmiron® · Interstitial cystitis (1996)
Elmiron® · Painful bladder syndrome (2017)
Elmiron® · Interstitial cystitis
FDA + EMA + TGA approved
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
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