GHRP-6 (10mg)
GHRP-6 (Growth Hormone-Releasing Peptide 6) is a synthetic hexapeptide that acts as a potent growth hormone secretagogue by binding to the ghrelin receptor (GHS-R1a). It stimulates pulsatile GH release while preserving normal feedback controls, leading to increased IGF-1 and potential anabolic benefits. This protocol outlines a three times daily subcutaneous approach.
Reviewed by the AllPeptides.eu Editorial Team·Last reviewed: 2026-06-16
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
⚠️ For informational/educational purposes only. Not medical advice. We do not sell any products. Self-treatment carries serious risks — consult a healthcare professional. Disclaimer
Research monograph
See the full GHRP-6 encyclopedia page with mechanism, evidence tier, related variants and research context.
How It Works
GHRP-6 acts as a synthetic ghrelin mimetic by binding to GHS-R1a in the pituitary and hypothalamus. It triggers an acute, pulsatile release of GH while simultaneously decreasing the inhibitory brake of somatostatin. It preserves normal feedback controls. Beyond endocrine effects, it exhibits cytoprotective properties via the CD36 receptor, activating cell survival pathways (PI3K/Akt) that protect tissues from oxidative stress and inflammation.
Quick Start
- Reconstitution: Add 3.0 mL bacteriostatic water → ~3.33 mg/mL concentration.
- Typical daily range: 300–900 mcg total (3 doses with gradual titration).
- Storage: Lyophilized: freezer −20 °C; post-reconstitution, refrigerator 2–8 °C; use within 7 days.
Typical / Gradual Approach (3 mL = ~3.33 mg/mL)
Route: Subcutaneously | Frequency: Three times daily
| Week | Dose | Units (per injection) |
|---|---|---|
| Weeks 1–2 | 100 mcg/injection | 3 Units (0.03 mL) |
| Weeks 3–4 | 200 mcg/injection | 6 Units (0.06 mL) |
| Weeks 5–12 | 300 mcg/injection | 9 Units (0.09 mL) |
Studies report administration three times daily subcutaneously, at least 4 hours apart (morning, midday, pre-bed). Half-life ~2.5 hours. Each injection on an empty stomach (2–3 hours after a meal, 30 minutes before eating).
Related compounds
Reconstitution Steps
- Draw 3.0 mL of bacteriostatic water.
- Inject slowly down the side of the vial; do not shake.
- Gently swirl/rotate until fully dissolved.
- Note the date; refrigerate at 2–8 °C; use within 7 days.
Protocol Overview
- Goal: Stimulate pulsatile GH release for muscle growth, fat loss, and recovery.
- Schedule: 3 subcutaneous injections daily for 8–12 weeks, at least 4 hours apart.
- Storage: Lyophilized frozen; reconstituted refrigerated; use within 7 days.
Dosing Protocol
- Start: 100 mcg/injection, 3× daily (300 mcg total) for Wk 1–2.
- Increase: 200 mcg/injection, 3× daily (600 mcg total) for Wk 3–4.
- Target: 300 mcg/injection, 3× daily (900 mcg total) for Wk 5–12.
- Timing: On an empty stomach; 4+ hours apart; 30 minutes before eating.
- Cycle Duration: 8–12 weeks; rotate sites.
- Break between cycles: After the cycle, a 4–6 week washout period is recommended. This break restores hormonal balance and GHSR sensitivity.
Washout & Cycle Restart
When can I restart?
After the cycle, a 4–6 week washout period is recommended. This break restores hormonal balance and GHSR sensitivity.
Minimum wait period: 4 weeks
Storage Instructions
- Lyophilized: Store at −20 °C in dry, dark conditions.
- Reconstituted: Refrigerate 2–8 °C; use within 7 days.
- Avoid freeze-thaw cycles.
Important Notes
- GHRP-6 can increase appetite due to its ghrelin-mimicking properties.
- Log daily doses, timing, and sites.
Potential Benefits & Side Effects
Potential Benefits:
- Muscle Growth & Fat Loss: Increased GH/IGF-1 support lean mass.
- Improved Recovery: Enhanced slow-wave sleep and faster tissue repair.
- Appetite Stimulation: Can increase hunger via ghrelin activation.
- Tissue Protection: Cardioprotection, neuroprotection, and anti-fibrotic effects.
Potential Side Effects:
- Transient mild increases in cortisol/ACTH.
- Increased appetite and potential water retention.
- Occasional injection site reactions.
- Generally well-tolerated in human trials.
⚠️ Serious Warnings & Long-Term Risks
The following warnings are based on published literature, FDA labels, and post-marketing surveillance. They do not constitute medical advice. Consult a healthcare professional.
Increased cortisol, prolactin & ghrelin
GHRP-6 significantly increases ghrelin (intense hunger), cortisol, and prolactin. May affect glycemic control and reproductive function.
📄 Eur J Endocrinol 1998References
- Eur J Endocrinol (1997) — Growth hormone-releasing peptides: a review
View Source - Clin Med Insights Cardiol (2017) — Synthetic GHRPs: cytoprotective effects
View Source - Eur J Pharm Sci (2013) — Pharmacokinetics of GHRP-6
View Source - Sex Med Rev (2018) — Safety of growth hormone secretagogues
View Source - Int Wound J (2018) — GHRP-6 prevents hypertrophic scarring
View Source
Recommended Supplements
L-Arginine + L-Ornithine
ZMA (Zinc + Magnesium + B6)
External Sources & Regulatory Status
Regulatory Approvals
Research-only — No regulatory approval
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
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