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    PNC-27: protocol variants and reconstitution resources

    Educational hub for PNC-27, grouping 1 available protocol variant with links to the exact dosage and reconstitution pages.

    What this hub covers

    This page groups the available PNC-27 protocol variants so readers can choose the exact vial-size guide without mixing formats.

    Reconstitution workflow

    Use the linked protocol pages and calculator resources to review concentration, diluent logic and unit conversions for the selected variant.

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    Available protocol variants

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    PNC-27

    30mg

    PNC-27 is an antineoplastic peptide that targets the HDM-2 receptor on cancer cells, inducing pore formation in their membrane and causing cell necrosis. It does not harm healthy cells. Research sources report subcutaneous administration of 100 mcg to 500 mcg, once daily, increased gradually.

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    Related research resources

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    References

    1. Davitt K et al. Ann Clin Lab Sci 2014 — The anti-cancer peptide, PNC-27, induces tumor cell necrosis of a poorly differentiated non-solid tissue human leukemia cell line that depends on expression of HDM-2 in the plasma membrane of these cells.
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    2. Sarafraz-Yazdi E et al. Biomedicines 2022 — PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis.
      View Source

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