Sermorelin + Ipamorelin (5mg + 5mg)
A classic GH secretagogue stack that combines two complementary pathways: Sermorelin (a GHRH analog, 29 amino acids) stimulates the GHRH receptor in the pituitary gland, while Ipamorelin (a selective ghrelin agonist) enhances GH secretion without increasing cortisol or prolactin. The synergy increases GH peaks by 3–5x compared to monotherapy.
Reviewed by the AllPeptides.eu Editorial Team·Last reviewed: 2026-06-16
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
⚠️ For informational/educational purposes only. Not medical advice. We do not sell any products. Self-treatment carries serious risks — consult a healthcare professional. Disclaimer
How It Works
**Sermorelin** binds to the GHRH-R in the anterior pituitary, increasing cAMP and activating GH transcription. **Ipamorelin** binds to the GHS-R1a (ghrelin receptor) in the pituitary, increasing intracellular Ca²⁺ levels and enhancing GH exocytosis. The **simultaneous activation** of both pathways (GHRH + Ghrelin) creates a synergistic, multiplicative effect on GH secretion, far greater than from single-agent administration.
Quick Start
- Sermorelin: 200–300 mcg SC, before bed
- Ipamorelin: 200–300 mcg SC, before bed (simultaneously)
- Cycle: 8–12 weeks on / 4 weeks off
- Storage: Refrigerator 2–8°C after reconstitution
Dosing Table — Sermorelin + Ipamorelin Stack
Route: Subcutaneous (SC) | Frequency: 1x/day (evening)
| Week | Dose | Units (per injection) |
|---|---|---|
| 1–2 | 200mcg Serm / 200mcg Ipa | 8 Units (0.08 mL) |
| 3–4 | 300mcg Serm / 200mcg Ipa | 12 Units (0.12 mL) |
| 5–12 | 300mcg Serm / 300mcg Ipa | 12 Units (0.12 mL) |
Both peptides are administered simultaneously before bed, on an empty stomach (2+ hours after the last meal). They can be mixed in the same syringe.
Related compounds
Reconstitution Steps
Dilution Selection
Peptides come in 3 mL, 5 mL or 10 mL vials. If your vial is smaller, the water amount adjusts automatically.
Sermorelin (5 mg)
Ipamorelin (5 mg)
⚠️ Units change depending on BAC water — always verify before administration. Based on
- Sermorelin (5 mg): Add 2.0 mL BAC water → 2.5 mg/mL (2,500 mcg/mL).
- Ipamorelin (5 mg): Add 2.0 mL BAC water → 2.5 mg/mL (2,500 mcg/mL).
- Swirl gently. They can be mixed in the same syringe if used simultaneously.
Protocol Overview
- Sermorelin (GRF 1-29) is a bioequivalent GHRH analog that physiologically stimulates the GHRH receptor on pituitary somatotroph cells.
- Ipamorelin is a penta-peptide (5 amino acids) that acts as a selective ghrelin agonist, increasing GH without raising cortisol, prolactin, or aldosterone.
- The combination activates two separate pathways (GHRH + Ghrelin) → synergistic GH release.
Dosing Protocol
- Administration: 200–300 mcg of each peptide, SC, 1x/day before bed.
- Titration: Start with 200 mcg/peptide for weeks 1–2, increase to 300 mcg from week 3+.
- Cycle: 8–12 weeks, followed by a 4-week pause.
- 5 days on / 2 off per week (weekdays) or daily — both schedules are effective.
- Break between cycles: A 4-week pause to avoid desensitization of GHRH/Ghrelin receptors.
Washout & Cycle Restart
When can I restart?
A 4-week pause to avoid desensitization of GHRH/Ghrelin receptors.
Minimum wait period: 4 weeks
Storage Instructions
- Lyophilized: −20 °C (12–24 months).
- Reconstituted: 2–8 °C, use within 3–4 weeks.
- Sermorelin is particularly sensitive to temperature — do not leave it out of the refrigerator.
Important Notes
- Sermorelin had FDA approval (Geref) but was commercially withdrawn (not for safety reasons).
- Ipamorelin does not increase cortisol — safer than GHRP-2/GHRP-6.
- Do not administer near high-fat/carbohydrate meals — insulin blocks GH.
- IGF-1 measurement is recommended before starting and 4 weeks after.
Potential Benefits & Side Effects
Potential Benefits:
- Synergistic increase in GH (3–5x vs monotherapy)
- Improved body composition (fat reduction, muscle gain)
- Improved sleep quality (deeper REM)
- Enhanced collagen and tissue regeneration
- Does not increase cortisol, prolactin, or aldosterone
- Physiological GH rhythm (pulsatile, not sustained)
Potential Side Effects:
- Mild redness at the injection site (10-15%)
- Transient headache (usually in week 1)
- Rare: numbness/tingling in fingers (GH-related)
- Very rare: fluid retention at high doses
⚠️ Serious Warnings & Long-Term Risks
The following warnings are based on published literature, FDA labels, and post-marketing surveillance. They do not constitute medical advice. Consult a healthcare professional.
Theoretical risk (IGF-1 elevation)
As a GHRH analogue, increases GH/IGF-1. Same theoretical concern as exogenous GH, but to a lesser degree due to physiological regulation.
📄 FDA Label — Geref® (withdrawn)Theoretical risk (GH/IGF-1 elevation)
As a GHS, increases GH. Theoretical risk for pre-existing neoplasms due to IGF-1 elevation. No clinical signal in short-term studies.
📄 Growth Horm IGF Res 2008References
- Sermorelin: a review of its use in the diagnosis and treatment of GH deficiency — Walker RF, Peptides, 2006.
View Source - Ipamorelin, a new growth-hormone-releasing peptide — Raun K et al., J Endocrinol, 1998.
View Source - Synergistic effects of GHRH and GHRP on GH secretion — Bowers CY, J Clin Endocrinol Metab, 1991.
View Source
Recommended Supplements
Multivitamin (High-Quality)
Magnesium Glycinate
Vitamin D3 + K2
Omega-3 Fish Oil (EPA/DHA)
Probiotics (Multi-Strain)
Electrolytes (Na, K, Mg)
Liver Support (NAC / Milk Thistle)
External Sources & Regulatory Status
Regulatory Approvals
Geref® · GH deficiency (children) (1997)
FDA approved (withdrawn 2008)
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
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