Epithalon + MOTS-C + SS-31 (10mg + 10mg + 10mg)

The combination targets three fundamental mechanisms of aging: **Epithalon** activates telomerase (hTERT), elongating telomeres and reversing cellular senescence (Hayflick limit). **MOTS-C** activates the AMPK → SIRT1 axis, optimizes mitochondrial metabolism, and regulates glucose. **SS-31** binds to cardiolipin, stabilizes complexes I–IV of the respiratory chain, reduces ROS by 40–60%, and prevents mitochondrial dysfunction. Together, they act on DNA (telomeres), metabolism (AMPK), and energy production (ETC) — the three pillars of biological aging.

• Epithalon: 5mg SC, 1x/day, 10–20 days
• MOTS-C: 5mg SC, 3x/week
• SS-31: 5mg SC, 1x/day
• Cycle: 4–6 weeks

1. Epithalon 10mg: Add 2ml of bacteriostatic water → 5mg/ml. Swirl gently.
2. MOTS-C 10mg: Add 2ml of bacteriostatic water → 5mg/ml. Swirl gently.
3. SS-31 10mg: Add 2ml of bacteriostatic water → 5mg/ml. Swirl gently.
4. Do not use NaCl — only bacteriostatic water (benzyl alcohol 0.9%).
5. Allow the powder to dissolve naturally — do not shake violently.

• This stack targets the three central mechanisms of aging simultaneously:
• Epithalon (Epitalon) — A tetrapeptide (Ala-Glu-Asp-Gly) that activates telomerase, elongating telomeres and slowing cellular senescence. Discovered by Prof. Vladimir Khavinson.
• MOTS-C — A mitochondrial peptide (16 amino acids) that regulates glucose metabolism, enhances AMPK, and improves insulin sensitivity. Encoded by mitochondrial DNA.
• SS-31 (Elamipretide) — A tetrapeptide (D-Arg-Dmt-Lys-Phe) that binds to cardiolipin on the inner mitochondrial membrane, stabilizing the electron transport chain.
• The synergy: Epithalon protects at the chromosomal level, MOTS-C optimizes mitochondrial function, and SS-31 prevents mitochondrial damage.

• Wk. 1 — Introduction: Epithalon 5mg SC in the evening, MOTS-C 5mg SC in the morning (3x/wk), SS-31 2.5mg SC in the morning.
• Wk. 2 — Full Dose: Increase SS-31 to 5mg/day. Epithalon and MOTS-C remain unchanged.
• Wk. 3–6 — Maintenance: Continue with full doses. MOTS-C is ideally taken before exercise.
• Epithalon is administered in the evening — melatonin enhances its action on the pineal gland.
• MOTS-C can be administered on exercise days for synergy via AMPK.
• Monitor energy levels, sleep quality, and exercise endurance.
• Break between cycles: After the cycle (4–6 weeks), a washout period of 8–12 weeks is recommended. Epithalon activates telomerase — the pause prevents chronic overstimulation. MOTS-C and SS-31 act at the mitochondrial level — the pause allows for assessment of results and natural homeostasis.

• All peptides (powder): -20°C for long-term storage, 2–8°C for short-term.
• After reconstitution: 2–8°C (refrigerator), away from light.
• Epithalon: Use within 28 days after reconstitution.
• MOTS-C: Use within 21 days after reconstitution.
• SS-31: Use within 21 days after reconstitution.
• Do not leave out of the refrigerator for more than 30 minutes.

• Investigational stack — no clinical studies exist for this triple combination.
• Epithalon has been researched for over 30 years (Khavinson Institute) with positive safety data.
• MOTS-C may lower glucose — caution is advised for diabetics on medication.
• SS-31 (Elamipretide) is in Phase III clinical trials (Barth Syndrome).
• A baseline blood panel is recommended before and after the cycle.
• Medical supervision is required.

1. Epithalon & Telomerase Activation — Khavinson VK, et al. Peptide Epitalon activates chromatin at the old age. Neuro Endocrinol Lett. 2003;24(3-4):233-240.
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2. Epithalon & Melatonin Regulation — Anisimov VN, et al. Effect of Epitalon on biomarkers of aging and lifespan in rats. Bull Exp Biol Med. 2003;135(1):31-34.
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3. MOTS-C Metabolic Regulation — Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis. Cell Metab. 2015;21(3):443-454.
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4. MOTS-C & Exercise Mimetic — Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline. Nat Commun. 2021;12(1):470.
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5. SS-31 Mitochondrial Protection — Szeto HH. First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics. Br J Pharmacol. 2014;171(8):2029-2050.
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6. SS-31 (Elamipretide) Clinical Trials — Karaa A, et al. A randomized crossover trial of elamipretide in adults with primary mitochondrial myopathy. J Cachexia Sarcopenia Muscle. 2020;11(4):909-918.
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7. Telomere Biology & Aging — Blackburn EH, et al. Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nat Med. 2006;12(10):1133-1138.
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