Dihexa + Semax + Cerebrolysin (10mg + 5mg + 60mg)

The combination works via three complementary mechanisms: **Dihexa** activates the HGF/c-Met receptor, promoting the formation of new synapses (synaptogenesis). **Semax** increases BDNF and NGF levels, enhancing neural plasticity and memory. **Cerebrolysin** provides ready-made neuropeptide growth factors that mimic the action of CNTF, GDNF, and IGF-1, supporting neural survival and regeneration. Together, they cover both the creation of new connections and the protection of existing neurons.

• Dihexa: 10mg sublingually, 1x/day (morning)
• Semax: 200–600mcg intranasally, 2x/day
• Cerebrolysin: 5ml IM, 5x/week
• Cycle: 4–6 weeks

1. Dihexa: Administered in capsules or sublingual tablets—no reconstitution required.
2. Semax: Comes in a nasal spray—ready to use.
3. Cerebrolysin: Comes in 5ml ampules—ready for IM injection, no dilution required.

• This stack combines three different mechanisms of neurocognitive enhancement:
• Dihexa — Angiotensin IV derivative, ~10 million times more potent than BDNF in synaptogenesis. Activates HGF/c-Met.
• Semax — Synthetic ACTH(4-10) analogue, increases BDNF, NGF, and dopamine. Approved in Russia.
• Cerebrolysin — Enzymatically derived peptide fractions of neural tissue, mimics the action of neurotrophic factors. Approved in 40+ countries.
• The combination targets: synaptogenesis (Dihexa), neurotrophic signaling (Semax), and neural regeneration (Cerebrolysin).

• Wk 1 — Introduction: Start with low doses to assess tolerance.
• Dihexa 5mg sublingually in the morning, Semax 200mcg/nostril morning+noon, Cerebrolysin 5ml IM.
• Wk 2 — Titration: Increase Dihexa to 10mg, Semax to 400mcg.
• Wk 3–6 — Full Dose: Dihexa 10mg, Semax 600mcg, Cerebrolysin 5ml.
• Cerebrolysin is administered 5 days/week (Mon-Fri) with a pause on weekends.
• Monitor cognitive performance, energy, sleep quality.
• Break between cycles: After the cycle (4–6 weeks), a washout period of 6–8 weeks is recommended. Dihexa enhances HGF/c-Met and Cerebrolysin provides neurotrophic factors—the pause prevents overstimulation and allows for assessment of results.

• Dihexa: -20°C powder, 2–8°C after opening.
• Semax: 2–8°C, away from light. Use within 30 days after opening.
• Cerebrolysin: Room temperature (up to 25°C), away from light. Do not use opened ampules.

• Investigational stack—no clinical studies exist for this specific triple combination.
• Dihexa may enhance angiogenesis—avoid in case of cancer history.
• Cerebrolysin contains animal-derived proteins—potential for allergy.
• Do not combine with MAOIs or potent serotonergics.
• Medical supervision is required throughout the cycle.
• Assess cognitive baseline before the cycle (e.g., MoCA test).

1. Dihexa & HGF/c-Met Synaptogenesis — McCoy AT, et al. A novel HGF/c-Met-enhancing peptide restores cognitive function in rats. J Pharmacol Exp Ther. 2013;344(2):431-440.
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2. Semax Neuroprotection & BDNF — Dolgikh VV, et al. Semax increases BDNF expression in rat brain. Dokl Biol Sci. 2009;428:428-430.
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3. Cerebrolysin in Alzheimer's Disease — Alvarez XA, et al. Cerebrolysin in Alzheimer's disease: a randomized, double-blind, placebo-controlled trial. J Neural Transm. 2006;113(11):1617-1629.
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4. Cerebrolysin Neurotrophic Activity — Windisch M. Cerebrolysin — from mechanism of action to clinical application. CNS Drug Rev. 2003;9(2):223-232.
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5. Semax Cognitive Enhancement — Ashmarin IP, et al. Semax: a regulatory peptide with nootropic activity. Neurosci Behav Physiol. 2005;35(3):277-281.
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6. Dihexa Cognitive Restoration — Benoist CC, et al. Dihexa, a novel cognitive enhancer with HGF/c-Met activity. J Pharmacol Exp Ther. 2014;349(2):260-268.
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