Triptorelin (GnRH) (2mg)

Triptorelin (D-Trp6-GnRH) is a synthetic decapeptide GnRH analog with a D-tryptophan substitution at position 6, which dramatically increases stability and potency (100× more potent than natural GnRH). In **micro-doses** (50–100 mcg), it acts as an acute GnRH agonist, causing a transient release of LH and FSH from the anterior pituitary. This 'wakes up' the HPG axis that was suppressed by exogenous substances. LH stimulates the Leydig cells of the testes to produce testosterone, while FSH supports spermatogenesis. **At high doses** (mg), continuous occupation of GnRH receptors causes downregulation via receptor internalization, leading to complete LH/FSH suppression — chemical castration. This is why dosing accuracy is of vital importance.

• Reconstitution: Add 2.0 mL bacteriostatic water → 1 mg/mL (1000 mcg/mL).
• PCT Dose: Single injection of 100 mcg (NOT mg) — 'one-shot PCT'.
• ⚠️ CRITICAL: 100 mcg ≠ 100 mg. Wrong unit = chemical castration. TRIPLE-check.

1. Withdraw 2.0 mL of bacteriostatic water.
2. Inject slowly against the wall · do not spray directly onto the powder.
3. Gently swirl until fully dissolved — do not shake.
4. Note the concentration (1 mg/mL = 1000 mcg/mL) and date.
5. Refrigerate at 2–8 °C · use within 28 days.

• Goal: Restart the HPG axis after an anabolic or exogenous testosterone cycle.
• Schedule: A single 100 mcg injection ('one-shot PCT') or a single 50 mcg injection + SERM.
• CRITICAL: Doses in mg (3.75+ mg) are used in prostate cancer therapy and cause chemical castration.
• Timing: Inject ONLY after exogenous compounds have fully cleared.

• One-Shot PCT: 100 mcg intramuscularly or subcutaneously — single injection.
• Low-Dose PCT: 50 mcg single injection + Tamoxifen 20mg/day or Clomid 25–50mg/day × 14–28 days.
• Timing: After full clearance of exogenous substances — depends on half-life.
• ⚠️ DO NOT repeat within 4 weeks — triptorelin has a potent effect on the HPG axis.
• Break between cycles: After injection, wait 4–6 weeks before evaluating your hormone panel. Do not use again without laboratory assessment.

• Lyophilized: −20 °C in dark, dry conditions.
• Reconstituted: Refrigerate 2–8 °C · use within 28 days.
• Avoid freeze-thaw cycles.

• ⚠️ CRITICAL DOSING WARNING: 100 mcg (micrograms), NOT 100 mg. Doses in mg cause chemical castration.
• Triptorelin is ~100× more potent than natural GnRH.
• Do not use if exogenous substances have not fully cleared.
• Single use — does not require cycles or repetitions in most cases.
• Check hormone panel (LH, FSH, testosterone) 4–6 weeks after.

1. Triptorelin: Pharmacological Properties and Clinical Use in Prostate Cancer — Triptorelin: a review of its pharmacological properties and clinical use in prostate cancer
   View Source
2. Triptorelin PCT Protocol: Dosage and Usage Guide — Sarms.io — Triptorelin PCT protocol: dosage and usage guide
   View Source
3. GnRH Agonist and Antagonist Mechanisms in Reproductive Medicine (PMC) — GnRH agonist and antagonist mechanisms in reproductive medicine
   View Source
4. Recovery of HPT Axis Function After Chronic Steroid Use — Recovery of hypothalamic-pituitary-testicular axis function after chronic steroid use
   View Source
5. Triptorelin Pamoate (Decapeptyl): European Assessment Report — EMA — Triptorelin pamoate (Decapeptyl): European assessment report
   View Source