PEG MGF (2mg)
PEG MGF is a pegylated variant of mechano-growth factor, an IGF-1 isoform activated in muscle tissue after mechanical stress or injury. Pegylation extends its half-life, allowing for once-daily subcutaneous administration.
Reviewed by the AllPeptides.eu Editorial Team·Last reviewed: 2026-06-16
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
⚠️ For informational/educational purposes only. Not medical advice. We do not sell any products. Self-treatment carries serious risks — consult a healthcare professional. Disclaimer
Research monograph
See the full MGF encyclopedia page with mechanism, evidence tier, related variants and research context.
How It Works
MGF is a splice variant of IGF-1 expressed in muscle tissue following mechanical loading or damage. Unlike systemic IGF-1, MGF acts locally to activate satellite cells and initiate muscle repair via its unique C-terminal E peptide. Pegylation extends its half-life, allowing for once-daily subcutaneous administration instead of frequent local injections.
Quick Start
- Reconstitution: Add 3.0 mL bacteriostatic water → ~0.667 mg/mL concentration.
- Typical daily range: 200–500 mcg once daily (titrated over 8 weeks).
- Storage: Lyophilized: −20 °C; reconstituted: 2–8 °C; avoid freeze-thaw cycles.
Titration Approach (3 mL = ~0.667 mg/mL)
Route: Subcutaneous | Frequency: Once daily
| Week | Dose | Units (per injection) |
|---|---|---|
| Weeks 1–2 | 200 mcg | 30 Units (0.30 mL) |
| Weeks 3–4 | 300 mcg | 45 Units (0.45 mL) |
| Weeks 5–6 | 400 mcg | 60 Units (0.60 mL) |
| Weeks 7–8 | 500 mcg | 75 Units (0.75 mL) |
Studies report administration once daily subcutaneously. Pegylation extends MGF's half-life, allowing for systemic subcutaneous dosing instead of frequent intramuscular injections.
Related compounds
Reconstitution Steps
- Withdraw 3.0 mL bacteriostatic water.
- Slowly inject down the side wall; avoid foaming.
- Gently swirl until dissolved (do not shake).
- Note date; refrigerate at 2–8 °C, away from light.
Protocol Overview
- Goal: Support muscle recovery and regeneration via satellite cell activation.
- Schedule: Daily subcutaneous injections for 8 weeks (extendable to 12–16 weeks).
- Storage: Lyophilized frozen; reconstituted refrigerated.
Dosing Protocol
- Initiation: 200 mcg daily; increase by ~100 mcg every 2 weeks.
- Target: 400–500 mcg daily in Weeks 5–8.
- Frequency: Once daily (subcutaneous).
- Cycle Duration: 8 weeks; optional extension to 12–16.
- Break between cycles: 4-week pause before repeating the cycle.
Washout & Cycle Restart
When can I restart?
4-week pause before repeating the cycle.
Minimum wait period: 4 weeks
Storage Instructions
- Lyophilized: −20 °C in dry, dark conditions.
- Reconstituted: 2–8 °C; avoid freeze-thaw cycles.
- Let vials reach room temperature before opening.
Important Notes
- No comprehensive clinical trials exist; results are only in animal and cell models.
Potential Benefits & Side Effects
Potential Benefits:
- Enhanced muscle, bone, and cartilage regeneration in animal models
- Promotes proliferation of myogenic precursor cells
- Improved muscle repair in injury models
Potential Side Effects:
- No comprehensive clinical trials; human safety is unknown
- Generally well-tolerated in preclinical models
- Potential mild local injection site reactions
⚠️ Serious Warnings & Long-Term Risks
The following warnings are based on published literature, FDA labels, and post-marketing surveillance. They do not constitute medical advice. Consult a healthcare professional.
Mechano Growth Factor — potential oncogenesis
MGF (IGF-1 Ec splice variant) promotes muscle hypertrophy and cell proliferation. Theoretical concern for enhancing neoplasms — especially in tissues with active mitosis.
📄 Growth Horm IGF Res 2004References
- Physiological Society – MGF — MGF: a local growth factor or a local tissue repair factor?
View Source - In Vivo (PubMed) — Expression of IGF-1 isoforms after exercise-induced muscle damage
View Source - International Orthopaedics (PubMed) — MGF E peptide promotes proliferation of osteoblasts in rabbits
View Source - Frontiers in Physiology (PubMed) — Skeletal muscle regeneration with MGF injection
View Source
Recommended Supplements
L-Arginine + L-Ornithine
ZMA (Zinc + Magnesium + B6)
External Sources & Regulatory Status
Regulatory Approvals
Research-only — Mechano Growth Factor
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
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