Pancragen (20mg)
Pancragen is a synthetic pancreatic bioregulator tetrapeptide (KEDW: Lys-Glu-Asp-Trp) studied for the regeneration and normalization of pancreatic tissue at the cellular level. It targets pancreatic cells, normalizes protein synthesis, and improves the function of both the endocrine (insulin) and exocrine (digestive enzymes) parts of the pancreas. This protocol presents subcutaneous administration once daily.
Reviewed by the AllPeptides.eu Editorial Team·Last reviewed: 2026-06-16
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
⚠️ For informational/educational purposes only. Not medical advice. We do not sell any products. Self-treatment carries serious risks — consult a healthcare professional. Disclaimer
How It Works
Pancragen is a pancreas-derived tetrapeptide (KEDW) that supports the regeneration and normalization of pancreatic tissue at the cellular level. It contains specific amino acid sequences that correspond to naturally occurring pancreatic regulatory peptides, allowing it to target pancreatic cells, normalize protein synthesis, and improve function. As a bioregulator, it can bind to DNA and regulate gene expression in specific tissues, with more fundamental and long-lasting effects compared to typical peptides.
Quick Start
- Reconstitution: Add 2.0 mL bacteriostatic water → 10 mg/mL concentration.
- Typical dose: 2 mg (20 units) once daily, for 20–30 days (typical) or every other day for 40–60 days (extended).
- Cycles: 2–3 cycles per year.
- Storage: Lyophilized: freezer −20 °C; after reconstitution, refrigerator 2–8 °C; avoid freeze-thaw cycles.
Dosing Protocol (2 mL = 10 mg/mL)
Route: Subcutaneous | Frequency: Once daily or every other day
| Week | Dose | Units (per injection) |
|---|---|---|
| Typical (Days 1–20/30) | 2 mg | 20 Units (0.20 mL) |
| Extended (Days 1–40/60) | 2 mg | 20 Units (0.20 mL) |
Studies report administration once daily (typical 20–30 day protocol) or every other day (extended 40–60 day protocol). Perform 2–3 cycles per year.
Related compounds
Reconstitution Steps
- Draw up 2.0 mL of bacteriostatic water.
- Inject slowly down the side of the vial; avoid foaming.
- Gently swirl/rotate until fully dissolved (do not shake vigorously).
- Note the date and refrigerate at 2–8 °C, protecting from light.
Protocol Overview
- Objective: Support pancreatic tissue regeneration, regulate insulin secretion, and improve metabolic homeostasis.
- Schedule: Subcutaneous injections for 20–30 days (typical) or 40–60 days (extended), 2–3 cycles/year.
- Dose: 2 mg per injection.
- Storage: Lyophilized frozen; reconstituted refrigerated; avoid freeze-thaw.
Dosing Protocol
- Typical protocol: 2 mg (20 units) daily for 20–30 days.
- Extended protocol: 2 mg (20 units) every other day for 40–60 days.
- Cycles: 2–3 cycles per year.
- Route: Subcutaneous administration.
- Timing: Any consistent time; rotate sites daily.
- Break between cycles: After the cycle (10–20 days), a pause of 3–6 months is recommended. Khavinson peptide bioregulators — typically 2–3 cycles/year.
Washout & Cycle Restart
When can I restart?
After the cycle (10–20 days), a pause of 3–6 months is recommended. Khavinson peptide bioregulators — typically 2–3 cycles/year.
Minimum wait period: 12 weeks
Storage Instructions
- Lyophilized: Store at −20 °C in dry, dark conditions.
- Reconstituted: Refrigerate at 2–8 °C for up to 2–4 weeks with bacteriostatic water; avoid freeze-thaw.
- Allow vials to reach room temperature before opening.
Important Notes
- May increase sensitivity to insulin, Metformin, GLP drugs, or SGLT2 inhibitors.
- Contraindication: Pregnancy/breastfeeding, acute severe pancreatitis, active pancreatic cancer.
- Use under medical supervision for uncontrolled Diabetes Mellitus, renal/hepatic insufficiency, autoimmune pancreatic conditions.
Potential Benefits & Side Effects
Potential Benefits:
- Regulates insulin secretion and glucose metabolism.
- Useful for reducing tolerance to GLP drugs.
- Optimal choice for preventing, mitigating, or reversing diabetic complications (neuropathy, vascular dysfunction).
- Reduces oxidative stress and inflammation in pancreatic cells.
- Supports islet cell regeneration and pancreas health.
- Accelerates recovery after pancreatitis or other pancreatic conditions.
- Improves insulin sensitivity.
- Enhances pancreatic response to metabolic stress or injury.
- Normalizes digestive enzyme secretion.
- Improves nutrient assimilation and pancreatic enzyme balance.
Potential Side Effects:
- Temporary fatigue or weakness (during metabolic adaptation).
- Injection site reaction (redness, swelling, itching).
- Headache.
- Mild dizziness.
- Mild gastrointestinal discomfort (nausea, bloating, indigestion).
- Blood sugar fluctuations during the initial dosing period.
- Rare: Temporary symptoms of immune activation (malaise, fever).
⚠️ Serious Warnings & Long-Term Risks
The following warnings are based on published literature, FDA labels, and post-marketing surveillance. They do not constitute medical advice. Consult a healthcare professional.
Pancreatic bioregulator — caution in diabetes
Modifies pancreatic β-cell function. Theoretical risk of glycemic dysregulation. Contraindicated without medical supervision in diabetics.
📄 Khavinson VK — Bull Exp Biol MedReferences
- Khavinson V.Kh. (2005) — Peptide bioregulation of aging: a review of pancreatic peptide bioregulators
View Source - MDPI Int J Mol Sci — Peptide regulation of gene expression: Khavinson bioregulators
View Source - PubMed (2016) — Peptide bioregulators: experimental and clinical studies of geroprotectors
View Source - Bull Exp Biol Med (2013) — Regulation of pancreatic β-cell function by peptides
View Source
Recommended Supplements
Multivitamin (High-quality)
External Sources & Regulatory Status
Regulatory Approvals
Панкраген® · Pancreatic bioregulation (2007)
Approved in Russia (Khavinson bioregulator)
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
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