HMG (Human Menopausal Gonadotropin) (75 IU)
HMG contains FSH and LH in a ~1:1 ratio and is used for spermatogenesis stimulation and fertility support. 75 IU vial with intramuscular or subcutaneous administration 3 times weekly.
Reviewed by the AllPeptides.eu Editorial Team·Last reviewed: 2026-06-16
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
⚠️ For informational/educational purposes only. Not medical advice. We do not sell any products. Self-treatment carries serious risks — consult a healthcare professional. Disclaimer
How It Works
HMG provides exogenous FSH and LH. FSH stimulates Sertoli cells for spermatogenesis, while LH stimulates Leydig cells to produce testosterone. The combination is essential for complete spermatogenesis.
Quick Start
- Reconstitution: Add 1.0 mL of bacteriostatic water → 75 IU/mL.
- Typical dose: 75 IU 3 times weekly.
- Storage: 2–8 °C after reconstitution.
Dosing Table — HMG 75 IU
Route: Subcutaneous / Intramuscular | Frequency: 3 times weekly
| Week | Dose | Units (per injection) |
|---|---|---|
| Weeks 1–12+ | 75 IU | 100 units (1.00 mL) × 3/week |
Studies report administration 75 IU three times weekly. It is often combined with HCG for full fertility support.
Related compounds
Reconstitution Steps
- Withdraw 1.0 mL of bacteriostatic water.
- Slowly inject into the vial.
- Swirl gently.
- Refrigerate at 2–8 °C.
Protocol Overview
- Goal: Stimulation of spermatogenesis via FSH + LH action.
- Schedule: 75 IU × 3/wk for 3–6 months.
- Combination: Often with HCG 1,000–1,500 IU × 2–3/wk.
Dosing Protocol
- Typical Dose: 75 IU × 3/wk.
- Duration: 3–6 months, evaluate with a semen analysis.
- Combination: HCG + HMG for optimal results.
- Break between cycles: After the cycle (3–6 months), a pause of 4–8 weeks and evaluation via semen analysis is recommended before restarting.
Washout & Cycle Restart
When can I restart?
After the cycle (3–6 months), a pause of 4–8 weeks and evaluation via semen analysis is recommended before restarting.
Minimum wait period: 4 weeks
Storage Instructions
- Lyophilized: 2–8 °C.
- Reconstituted: 2–8 °C · use immediately or within 24 hours.
Important Notes
- Requires medical monitoring of hormones.
- Spermatogenesis takes 3+ months to show results.
- Use sterile technique.
Potential Benefits & Side Effects
Potential Benefits:
- Stimulation of spermatogenesis.
- Fertility support in hypogonadism.
- Synergistic action of FSH + LH.
Potential Side Effects:
- Possible local reaction at the injection site.
- Rare gynecomastia at high doses.
- Requires estradiol monitoring.
⚠️ Serious Warnings & Long-Term Risks
The following warnings are based on published literature, FDA labels, and post-marketing surveillance. They do not constitute medical advice. Consult a healthcare professional.
OHSS & multiple pregnancies
HMG (Menopur®) can cause severe OHSS and multiple pregnancies. Requires medical monitoring with ultrasound.
📄 FDA Label — Menopur®References
- Journal of Clinical Endocrinology — HMG for male infertility
View Source - Human Reproduction — FSH/LH therapy and spermatogenesis
View Source
Recommended Supplements
CoQ10 (Ubiquinol)
Folate (5-MTHF)
Omega-3 (DHA)
External Sources & Regulatory Status
Regulatory Approvals
Menopur® · Infertility (1996)
Menopur® · Infertility
FDA + EMA approved
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
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