HCG (Human Chorionic Gonadotropin) (5000 IU)
HCG (Human Chorionic Gonadotropin) is a glycoprotein hormone that mimics the action of LH. It is used to maintain testicular function, support fertility, and as an adjunct to testosterone replacement therapy (TRT). 5,000 IU vial administered subcutaneously or intramuscularly.
Reviewed by the AllPeptides.eu Editorial Team·Last reviewed: 2026-06-16
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
⚠️ For informational/educational purposes only. Not medical advice. We do not sell any products. Self-treatment carries serious risks — consult a healthcare professional. Disclaimer
How It Works
HCG binds to the LH receptor in Leydig cells, stimulating intratesticular testosterone production. It maintains testicular volume and supports spermatogenesis during exogenous testosterone administration.
Quick Start
- Reconstitution: Add 2.0 mL of bacteriostatic water → 2,500 IU/mL.
- Typical Range: 250–500 IU 2–3 times weekly.
- Easy Measurement: At 2,500 IU/mL, 10 units = 250 IU.
- Storage: 2–8 °C after reconstitution · use within 30 days.
Dosing Table — HCG 5,000 IU
Route: Subcutaneous / Intramuscular | Frequency: 2–3 times weekly
| Week | Dose | Units (per injection) |
|---|---|---|
| TRT Support | 250 IU | 10 units (0.10 mL) × 2–3/wk |
| Fertility | 500 IU | 20 units (0.20 mL) × 3/wk |
| HPTA Restart | 1.000–1.500 IU | 40–60 units × 3/wk (short cycle) |
Studies report administration 2–3 times weekly at regular intervals. The dose depends on the goal (TRT, fertility, PCT).
Related compounds
Reconstitution Steps
- Withdraw 2.0 mL of bacteriostatic water.
- Inject slowly down the side wall of the vial.
- Gently swirl until fully dissolved.
- Refrigerate at 2–8 °C · note the date.
Protocol Overview
- Goal: Maintain testicular function, support spermatogenesis, prevent atrophy during TRT.
- Schedule: Continuous use alongside TRT or short PCT cycle.
Dosing Protocol
- TRT: 250 IU × 2–3/wk.
- Fertility: 500 IU × 3/wk.
- PCT: 1,000–1,500 IU × 3/wk for 2–3 weeks.
- Break between cycles: For PCT: after 2–3 weeks, pause for 4–6 weeks. On TRT: used continuously alongside—no cycling required.
Washout & Cycle Restart
When can I restart?
For PCT: after 2–3 weeks, pause for 4–6 weeks. On TRT: used continuously alongside—no cycling required.
Minimum wait period: 4 weeks
Storage Instructions
- Lyophilized: 2–8 °C.
- Reconstituted: 2–8 °C · use within 30 days.
Important Notes
- Do not exceed 1,500 IU per dose without medical supervision.
- Monitor estradiol on high doses.
Potential Benefits & Side Effects
Potential Benefits:
- Maintains testicular volume during TRT.
- Supports spermatogenesis and fertility.
- Increases endogenous testosterone.
- Improves well-being and libido.
Potential Side Effects:
- Potential increase in estradiol.
- Fluid retention at high doses.
- Nipple sensitivity (rare at low doses).
⚠️ Serious Warnings & Long-Term Risks
The following warnings are based on published literature, FDA labels, and post-marketing surveillance. They do not constitute medical advice. Consult a healthcare professional.
OHSS (Ovarian Hyperstimulation Syndrome)
In women, HCG can cause severe OHSS (ascites, thromboembolism, renal failure). In men, possible gynecomastia from aromatization.
📄 FDA Label — Pregnyl®References
- Journal of Clinical Endocrinology & Metabolism — HCG for maintenance of intratesticular testosterone during TRT
View Source - Fertility and Sterility — HCG and spermatogenesis
View Source
Recommended Supplements
CoQ10 (Ubiquinol)
Folate (5-MTHF)
Omega-3 (DHA)
External Sources & Regulatory Status
Regulatory Approvals
Pregnyl® / Ovidrel® · Infertility / Ovulation induction (1975)
Ovitrelle® · Infertility
Infertility
Approved worldwide
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
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