Glutathione (1500mg)

Glutathione (GSH) is the most abundant intracellular antioxidant at 1–10 mM concentrations. As a glutamate-cysteine-glycine tripeptide, it acts as a primary thiol redox buffer, neutralizing reactive oxygen species (ROS), supporting Phase II detoxification pathways, and facilitating xenobiotic and heavy metal excretion. The reduced form (GSH) donates electrons and is recycled from the oxidized form (GSSG) via glutathione reductase (NADPH-dependent). The subcutaneous route bypasses extensive breakdown by intestinal γ-glutamyltransferases, allowing for higher systemic bioavailability compared to oral administration.

• Vial: 1500 mg powder in a 10 mL vial.
• Reconstitution: Add 10.0 mL bacteriostatic water → 150 mg/mL concentration.
• Weekly Range: 600–1500 mg/week (3 injections/week).
• Easy Titration (U-100): 1 unit = 0.01 mL = 1.5 mg · 67 units = 100 mg · 83 units = 125 mg · 100 units = 150 mg.
• Storage: Lyophilized: −20 °C· reconstituted: 2–8 °C, use within 14–21 days, do not refreeze.

1. Draw 10.0 mL bacteriostatic water into a transfer syringe.
2. Inject slowly down the vial's inner wall; avoid direct stream onto powder & foaming.
3. Gently swirl until fully dissolved — DO NOT SHAKE (glutathione is fragile).
4. Note reconstitution date; refrigerate at 2–8 °C; use within 14–21 days.

• Goal: Antioxidant defense, liver detoxification, immune support, skin health.
• Schedule: 3 subcutaneous injections/week × 8–12 weeks.
• Weekly Dose: 600 → 900 → 1500 mg (gradual titration).
• Cycle: 8–12 weeks ON / 4–8 weeks OFF.
• Storage: Lyophilized −20 °C · Diluted 2–8 °C (14–21 days) · no refreeze.

• Uptake Phase (Weeks 3–4): 300 mg × 3/wk — replenish intracellular GSH stores.
• Maintenance Phase (Weeks 5–12): 500 mg × 3/wk = 1500 mg/week — split each dose into 4 × 125 mg at separate sites (adhering to 100 unit/injection limit).
• Frequency: Monday / Wednesday / Friday or equivalent pattern.
• Cycle Duration: 8–12 weeks active use.
• Washout: 4–8 weeks before restarting.
• Break between cycles: After an 8–12 week cycle, a 4–8 week break is recommended for reassessment and to prevent endogenous synthesis adaptation.

• Lyophilized: Store at −20 °C in dry, dark conditions; stable for months.
• Reconstituted: Refrigerate 2–8 °C; use within 14–21 days; DO NOT refreeze.
• Glutathione is unstable in solution — prioritize immediate use post-reconstitution when feasible.
• Protect from light; store upright; do not expose to room temperature for extended periods.

• 100 Unit/Injection Limit: At 150 mg/mL every dose must be split across separate sites: 200 mg → 2 × 100 mg, 300 mg → 2 × 150 mg, 500 mg → 4 × 125 mg.
• Do not shake vial — only gentle swirling; agitation may denature the peptide.
• Record reconstitution date on vial and log dosing schedule.

1. Antioxidant Glutathione: Protective Roles and Regeneration Mechanisms — Antioxidant Glutathione: Protective Roles and Regeneration Mechanisms
   View Source
2. Glutathione and Dependent Enzymes: Coordinated Defense Against Oxidative Stress — Glutathione and Dependent Enzymes: Coordinated Defense Against Oxidative Stress
   View Source
3. Glutathione: Roles in Immune Function, Detoxification and Clinical Applications (PMC) — Glutathione: Roles in Immune Function, Detoxification and Clinical Applications
   View Source
4. Glutathione Efficacy in NAFLD Treatment: Open-Label Pilot Study (PMC) — Glutathione Efficacy in NAFLD Treatment: Open-Label Pilot Study
   View Source
5. Glutathione Anti-Aging and Anti-Melanogenic Effects: RCT (PMC) — Glutathione Anti-Aging and Anti-Melanogenic Effects: RCT
   View Source