FTPP (Adipotide) (5mg)
FTPP (Adipotide) targets adipose tissue vasculature, inducing apoptosis. Reconstitute with 2.5mL of bacteriostatic water to yield 2mg/mL. Experimental peptide.
Reviewed by the AllPeptides.eu Editorial Team·Last reviewed: 2026-06-16
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
⚠️ For informational/educational purposes only. Not medical advice. We do not sell any products. Self-treatment carries serious risks — consult a healthcare professional. Disclaimer
How It Works
FTPP binds to prohibitin on adipose tissue endothelial cells, triggering their apoptosis. This vascular destruction leads to ischemia and necrosis of adipocytes.
Quick Start
- Typical dose: 100–500mcg subcutaneously
- Frequency: 1x/day
- Storage: 2–8°C after reconstitution
Dosing Table — FTPP 5mg
Route: Subcutaneous injection | Frequency: 1x daily
| Week | Dose | Units (per injection) |
|---|---|---|
| 1 | 100mcg | 5 Units (0.05 mL) |
| 2–3 | 200mcg | 10 Units (0.10 mL) |
| 4+ | 500mcg | 25 Units (0.25 mL) |
Maximum 4-week cycle. Nephrotoxicity has been reported in studies—monitor renal function.
Related compounds
Reconstitution Steps
- Clean the vial stoppers with an alcohol swab.
- Draw 2.5mL of bacteriostatic water.
- Inject slowly down the side of the vial.
- Gently swirl until fully dissolved.
- Store in the refrigerator (2–8°C).
Protocol Overview
- FTPP (Fat-Targeted Proapoptotic Peptide) targets the prohibitin receptor.
- It selectively destroys the blood vessels that supply adipose tissue.
- Experimental—tested only in rhesus macaques.
Dosing Protocol
- Start with 100mcg/day.
- Increase to 200–500mcg/day after assessment.
- Cycle: maximum 4 weeks.
- MANDATORY monitoring of creatinine/BUN.
- Break between cycles: After a cycle (maximum 4 weeks), a washout period of 8–12 weeks is recommended. FTPP is nephrotoxic—complete recovery of renal function is required.
Washout & Cycle Restart
When can I restart?
After a cycle (maximum 4 weeks), a washout period of 8–12 weeks is recommended. FTPP is nephrotoxic—complete recovery of renal function is required.
Minimum wait period: 8 weeks
Storage Instructions
- Reconstituted: 2–8°C, use within 14 days.
- Powder: -20°C.
Important Notes
- ⚠️ EXPERIMENTAL—high risk of nephrotoxicity.
- Monitor renal function weekly.
- STRICTLY for use under medical supervision only.
Potential Benefits & Side Effects
Potential Benefits:
- Targeted destruction of adipose tissue
- Significant reduction in body fat (in monkeys)
- Improved insulin sensitivity
- Reduction of visceral fat
Potential Side Effects:
- ⚠️ Nephrotoxicity (reported in studies)
- Dehydration
- Proteinuria
- High risk—experimental
⚠️ Serious Warnings & Long-Term Risks
The following warnings are based on published literature, FDA labels, and post-marketing surveillance. They do not constitute medical advice. Consult a healthcare professional.
Adipocyte destruction — potential local risks
FTPP (adipotide) targets adipose tissue vasculature, causing necrosis. In primates, reversible renal tubular damage was observed.
📄 Sci Transl Med 2011Nephrotoxicity (animal models)
In rhesus monkeys, FTPP caused dose-dependent kidney damage (elevated creatinine). Reversible after discontinuation, but serious concern.
📄 Sci Transl Med 2011References
- Adipotide Fat Reduction — Barnhart KF, et al. A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys. Sci Transl Med. 2011;3(108):108ra112.
View Source - FTPP Mechanism — Kolonin MG, et al. Reversal of obesity by targeted ablation of adipose tissue. Nat Med. 2004;10(6):625-632.
View Source
External Sources & Regulatory Status
Regulatory Approvals
Research-only — Adipotide (preclinical)
Educational information. Not medical advice, and no efficacy claim is implied. Regulatory approval is not a use recommendation by AllPeptides.eu.
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