AICAR (100mg)

AICAR directly activates AMP-activated protein kinase (AMPK), increasing fatty acid oxidation, glucose uptake into muscles, mitochondrial biogenesis, and angiogenesis — processes normally activated by aerobic exercise.

• Reconstitution: Add 5.0 mL bacteriostatic water → 20 mg/mL concentration.
• Literature-reported range: 1–3 mg once daily (gradual titration).
• Easy measurement: At 20 mg/mL, 1 unit = 0.01 mL = 200 mcg on a U-100 syringe.
• Storage: Lyophilized: −20 °C; reconstituted: 2–8 °C, use within 28 days.

1. Draw 5.0 mL of bacteriostatic water.
2. Inject slowly down the vial wall; avoid foaming.
3. Swirl gently until fully dissolved — do not shake.
4. Note the reconstitution date and refrigerate at 2–8 °C.

• Literature-reported scope: AMPK activation, glucose and fatty-acid metabolism (mostly preclinical data).
• Literature-described schedule: 1 → 2 → 3 mg daily over 8 weeks.

• Weeks 1–2: 1 mg daily.
• Weeks 3–4: 2 mg daily.
• Weeks 5–8: 3 mg daily.
• Literature-described break: 4 weeks after the cycle.
• Break between cycles: After the 8-week cycle, the literature describes a 4-week break.

• Lyophilized: −20 °C in dry, dark conditions.
• Reconstituted: 2–8 °C; use within 28 days.
• Avoid freeze-thaw cycles.

• WADA-banned substance.
• For research use only.
• May affect blood glucose.

1. AICAR Activates AMPK in Skeletal Muscle — Cell (2008) — AICAR AMPK activation in muscle
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2. AICAR as Exercise Mimetic in Mice — PNAS (2008) — AICAR exercise mimetic in mice
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