Research Use Only
MOTS-C vs 5-Amino-1MQ
Neutral RUO comparison of MOTS-C and 5-Amino-1MQ using public protocol-library fields: vial size, research class, mechanism, evidence level and references.
Public fields onlyReferences included
This page compares only public, research-context fields from the AllPeptides protocol library. It is not a ranking, recommendation, safety comparison or human-use guide.
Public research comparison fields
| Field | MOTS-C | 5-Amino-1MQ |
|---|---|---|
| Name | MOTS-C | 5-Amino-1MQ |
| Representative vial size | 5mg | 10mg |
| Research class | Mitochondrial / longevity research | Other research context |
| Mechanism context | MOTS-c acts as a metabolic "stress signal" that helps optimize energy use during nutritional pressure or exercise. Its primary mechanism is AMPK activation through inhibition of the folate cycle, causing accumulation of AICAR (an AMP analogue). Activated AMPK shifts cells into an energy-efficiency mode — enhancing glucose uptake, fatty acid oxidation and mitochondrial respiration, while reducing fat storage and gluconeogenesis. MOTS-c can also translocate to the nucleus under stress conditions and upregulate antioxidant and stress-response genes. Its action resembles that of exercise and metformin at the cellular level. | 5-Amino-1MQ (5-amino-1-methylquinolinium) is a synthetic small molecule that selectively inhibits Nicotinamide N-methyltransferase (NNMT). NNMT is an enzyme that methylates nicotinamide (vitamin B3) using S-adenosylmethionine (SAM) as the methyl donor. In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability. By inhibiting NNMT, 5-Amino-1MQ may spare nicotinamide for NAD+ synthesis, activating SIRT1 pathways associated with mitochondrial biogenesis and fat oxidation. |
| Evidence level | Not specified in profile | Not specified in profile |
Combined references
- Cell Metabolism (2015) — MOTS-c promotes metabolic homeostasis, reduces obesity and insulin resistance
View source - J Translational Medicine (2023) — MOTS-c: effects and mechanisms in stress, metabolism and aging
View source - J Mol Medicine (2019) — MOTS-c regulates adipose homeostasis in an ovariectomy model
View source - Nature Communications (2021) — MOTS-c regulator of age-related physical decline and muscle homeostasis
View source - USADA Spirit of Sport (2023) — What is the MOTS-c peptide?
View source - Kraus D et al. Nature 2014 — NNMT inhibition protects against diet-induced obesity
View source - PMC (2024) — NNMT inhibition mitigates obesity-related metabolic dysfunction
View source - Frontiers in Pharmacology (2024) — NNMT: a novel therapeutic target for metabolic syndrome
View source - PubMed (2021) — Pharmacokinetic study of 5-amino-1-methylquinolinium
View source - Journal of Medicinal Chemistry (ACS) — NNMT inhibitors with enhanced potency
View source