Research Use Only
CJC-1295 DAC vs CJC-1295 (No DAC) / Mod GRF 1-29
Neutral RUO comparison of CJC-1295 DAC and CJC-1295 (No DAC) / Mod GRF 1-29 using public protocol-library fields: vial size, research class, mechanism, evidence
Public fields onlyReferences included
This page compares only public, research-context fields from the AllPeptides protocol library. It is not a ranking, recommendation, safety comparison or human-use guide.
Public research comparison fields
| Field | CJC-1295 DAC | CJC-1295 (No DAC) / Mod GRF 1-29 |
|---|---|---|
| Name | CJC-1295 DAC | CJC-1295 (No DAC) / Mod GRF 1-29 |
| Representative vial size | 2mg | 2mg |
| Research class | GH / secretagogue research | GH / secretagogue research |
| Mechanism context | CJC-1295 DAC is a modified 30-amino-acid GHRH analogue conjugated to a Drug Affinity Complex (DAC) that binds covalently to serum albumin after injection. This albumin binding dramatically extends the half-life from minutes to approximately 6-8 days, allowing weekly dosing. It binds to GHRH receptors on pituitary somatotroph cells, enhancing GH synthesis and pulsatile release. Importantly, it increases basal GH levels while preserving the natural GH pulse rhythm. Clinical trials show sustained GH increases of 2-10 fold and IGF-1 of 1.5-3 fold, with elevated IGF-1 persisting up to 28 days after multiple doses. | Mod GRF 1-29 stimulates the GHRH receptor in the pituitary, activating pulsatile growth hormone secretion. Unlike CJC-1295 DAC, its short half-life preserves the physiological pulsatile pattern. |
| Evidence level | Not specified in profile | Not specified in profile |
Combined references
- J Clin Endocrinol Metab — Sustained GH and IGF-1 stimulation by CJC-1295 in healthy adults
View source - Jetté L et al. Endocrinology 2005 — Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog.
View source - Growth Hormone & IGF Research — Activation of the GH/IGF-1 axis by CJC-1295
View source - Body Composition and Quality of Life in GH-Deficient Adults — Body composition and quality of life in adults with GH deficiency
View source - Physiology of Growth Hormone Secretion During Sleep — Physiology of growth hormone secretion during sleep
View source - Teichman SL et al. J Clin Endocrinol Metab 2006 — Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.
View source