What is Mazdutide? Dual GLP-1 and Glucagon Agonist
Summary
Mazdutide is a weekly oxyntomodulin-based peptide that co-activates GLP-1 and glucagon receptors to reduce appetite and increase energy expenditure, achieving clinically significant weight loss in randomized trials. It received its first approvals in China in 2025.
Substance Properties
What is Mazdutide?
Mazdutide (IBI-362 / LY3305677) is a weekly dual GLP-1 and glucagon receptor agonist, designed based on oxyntomodulin. In phase 2 and 3 studies, Mazdutide produced clinically significant weight loss along with improvements in multiple metabolic markers. China granted the first marketing approvals in 2025.
Mechanism of action
Acting simultaneously on GLP-1 and glucagon receptors, Mazdutide reduces appetite (GLP-1) while increasing energy expenditure (glucagon). This dual mechanism theoretically offers advantages over GLP-1 mono-agonists like semaglutide.
Clinical results
In randomized clinical trials in Chinese adults with overweight/obesity, Mazdutide achieved mean weight loss exceeding 10% at 24 weeks. Additionally, it improved glycemic control, blood lipids, and liver function markers.
Comparison with Semaglutide and Tirzepatide
While semaglutide (Ozempic/Wegovy) is a GLP-1 mono-agonist and tirzepatide (Mounjaro) is a dual GLP-1/GIP, Mazdutide targets GLP-1 and glucagon. The glucagon component theoretically increases energy metabolism, but head-to-head trials are needed for definitive comparisons.
Related Guides
Frequently Asked Questions (FAQ)
Is Mazdutide available?
Mazdutide received marketing approvals in China in 2025. It is not yet approved in Europe or the US.
What are the most common side effects?
As with other GLP-1 agonists, gastrointestinal side effects (nausea, vomiting, diarrhea) are the most common, particularly during dose escalation.
References & Studies
Disclaimer
This article is exclusively educational for researchers. It does not constitute medical advice.
⚠️ For informational/educational purposes only. Not medical advice. We do not sell any products. Self-treatment carries serious risks — consult a healthcare professional. Disclaimer